A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction
Identifieur interne : 000740 ( Main/Exploration ); précédent : 000739; suivant : 000741A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction
Auteurs : X George Xu [États-Unis] ; Bryan Bednarz [États-Unis] ; Harald Paganetti [États-Unis]Source :
- Physics in medicine and biology [ 0031-9155 ] ; 2008.
Abstract
It has been long known that patients treated with ionizing radiation carry a risk of developing a second cancer in their lifetimes. Factors contributing to the recently renewed concern about the second cancer include improved cancer survival rate, younger patient population as well as emerging treatment modalities such as intensity-modulated radiation treatment (IMRT) and proton therapy that can potentially elevate secondary exposures to healthy tissues distant from the target volume. In the past 30 years, external-beam treatment technologies have evolved significantly, and a large amount of data exist but appear to be difficult to comprehend and compare. This review article aims to provide readers with an understanding of the principles and methods related to scattered doses in radiation therapy by summarizing a large collection of dosimetry and clinical studies. Basic concepts and terminology are introduced at the beginning. That is followed by a comprehensive review of dosimetry studies for external-beam treatment modalities including classical radiation therapy, 3D-conformal x-ray therapy, intensity-modulated x-ray therapy (IMRT and tomotherapy) and proton therapy. Selected clinical data on second cancer induction among radiotherapy patients are also covered. Problems in past studies and controversial issues are discussed. The needs for future studies are presented at the end.
Url:
DOI: 10.1088/0031-9155/53/13/R01
PubMed: 18540047
PubMed Central: 4009374
Affiliations:
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Polytechnic Institute, Troy, NY 12180</wicri:regionArea><wicri:noRegion>NY 12180</wicri:noRegion></affiliation></author><author><name sortKey="Paganetti, Harald" sort="Paganetti, Harald" uniqKey="Paganetti H" first="Harald" last="Paganetti">Harald Paganetti</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author></analytic><series><title level="j">Physics in medicine and biology</title><idno type="ISSN">0031-9155</idno><idno type="eISSN">1361-6560</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">It has been long known that patients treated with ionizing radiation carry a risk of developing a second cancer in their lifetimes. Factors contributing to the recently renewed concern about the second cancer include improved cancer survival rate, younger patient population as well as emerging treatment modalities such as intensity-modulated radiation treatment (IMRT) and proton therapy that can potentially elevate secondary exposures to healthy tissues distant from the target volume. In the past 30 years, external-beam treatment technologies have evolved significantly, and a large amount of data exist but appear to be difficult to comprehend and compare. This review article aims to provide readers with an understanding of the principles and methods related to scattered doses in radiation therapy by summarizing a large collection of dosimetry and clinical studies. Basic concepts and terminology are introduced at the beginning. That is followed by a comprehensive review of dosimetry studies for external-beam treatment modalities including classical radiation therapy, 3D-conformal x-ray therapy, intensity-modulated x-ray therapy (IMRT and tomotherapy) and proton therapy. Selected clinical data on second cancer induction among radiotherapy patients are also covered. Problems in past studies and controversial issues are discussed. 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